Welcome to Lipids@Wayne
Lipids@Wayne is a program of Wayne State University researchers from the School of Medicine, Physics and the College of Liberal Arts and Sciences. Now in our seventh year, our twice-monthly presentations focus on cutting-edge research and technological advances in lipid research and lipidomics. These meetings have led to very fruitful collaborations.
In addition to these presentations, we sponsor an annual symposium that addresses the vital roles of lipids in cellular processes required for normal physiological function. The symposium features excellent plenary lectures from outstanding invited speakers at the cutting edge of lipid research. A poster session is also featured, which fosters discussion and sharing of research findings. Awards are given for the most outstanding posters presented by graduate students, post-doctoral fellows, and residents.
The methyl sink function for phospholipid and histone methylation
Wednesday, December 5th, 4PM (New Time!)
Cunqi Ye, Ph.D.
Department of Biochemistry
UT Southwestern Medical Center
Abstract: Methylation of phosphatidylethanolamine (PE) is a conventional pathway for the synthesis of phosphatidylcholine (PC), the most abundant phospholipid in eukaryotic biomembranes. Defects in PE methylation have been found innonalcoholic fatty liver disease and aging hearts. My study demonstrates that methylation of PE is the major consumer of methyl donor S-adenosylmethionine (SAM) and is required for the efficient synthesis of cysteine and glutathione. Cells lacking phospholipid methylation accumulate SAM, which leads to hypermethylation of histones and the major phosphatase PP2A, dependency on cysteine, and sensitivity to oxidative stress. These findings underscore an underappreciated membrane-to-chromatin communication, which further led to the discovery of histones as a nuclear methyl sink. I found that such a metabolic function for bulk histone methylation could supersede a role in transcriptional regulation. Overall, these findings reveal an unforeseen metabolic function for phospholipid and histone methylation intrinsic to the life of a cell.
Seminars are every first & third Wednesday of the month at 5:00 p.m. in Biological Sciences Room 1167 on Main Campus. Pizza and beverages are served at each seminar.
How can you get involved?
We are always looking for newcomers at both our seminars and annual symposium. Those interested should check the seminar schedule and attend! We welcome all research groups from all departments, even if your primary focus is not lipids.
If you would like to be added to our e-mail list for seminar reminders and other Lipids@Wayne related information, please send an e-mail to email@example.com.