Welcome to Lipids@Wayne
Lipids@Wayne is a program of Wayne State University researchers from the School of Medicine, Physics and the College of Liberal Arts and Sciences. Now in our seventh year, our twice-monthly presentations focus on cutting-edge research and technological advances in lipid research and lipidomics. These meetings have led to very fruitful collaborations.
In addition to these presentations, we sponsor an annual symposium that addresses the vital roles of lipids in cellular processes required for normal physiological function. The symposium features excellent plenary lectures from outstanding invited speakers at the cutting edge of lipid research. A poster session is also featured, which fosters discussion and sharing of research findings. Awards are given for the most outstanding posters presented by graduate students, post-doctoral fellows, and residents.
Toward a Membrane Biophysics Understanding of CNS Myelin Physiology
Wednesday, April 3rd, 4PM
Alexdaner Gow, Ph.D.
Center for Molecular Medicine and Genetics
Wayne State University
The disconnection hypothesis, developed by Carl Friston and subsequently expanded to account for the symptomatology of neuropsychiatric and several neurodegenerative diseases, specifies that aberrant behavior stems from primary disruptions to neuron biology – neurotransmitter imbalance, aberrant neurogenesis and other salient pathology. In contrast, disconnection syndrome postulates the etiology of seemingly analogous behavioral deficits in terms of disrupting inter-regional myelinated fiber tracts, which isolates sensory integration and processing nodes. Although both explanations are likely complimentary, disconnection syndrome is largely routed in clinical medicine and considered phenomenological or anecdotal.
In recent work, we have developed a molecular model for characterizing disconnection syndrome, by modifying the passive electrical properties of CNS myelin sheaths in Claudin 11 knockout mice. These mutants exhibit behavioral deficits and neurotransmitter imbalance in the apparent absence of neurodegenerative pathology. To further our mechanistic understanding of this model, we have defined the physiological function of claudin 11. Our next step is to understand the consequences of claudin 11 loss-of-function in terms of membrane biophysics. Potentially, such an understanding may reveal pathways by which myelin passive properties can be pharmacologically manipulated to mitigate the impact of disconnection syndrome in disease.
Seminars are every first & third Wednesday of the month at 4:00 p.m. (new time) in Biological Sciences 1167 (seminar room) on Main Campus. Pizza and beverages are served at each seminar.
How can you get involved?
We are always looking for newcomers at both our seminars and annual symposium. Those interested should check the seminar schedule and attend! We welcome all research groups from all departments, even if your primary focus is not lipids.
If you would like to be added to our e-mail list for seminar reminders and other Lipids@Wayne related information, please send an e-mail to email@example.com.