About Us

What is Lipids @ Wayne?
Current Member Labs
Seminar Schedule
Annual Symposium

Regular Seminars

Every first & third Wednesday of the month at 5:00pm in Room 1167 Biological Sciences on Main Campus. Pizza and beverages are served at each seminar.
(See seminar schedule for dates and presenters)

2017 Lipids@Wayne Symposium

Thank you to everyone for participating in a wonderful symposium!

Learn more and see photos from the event


Welcome to Lipids @ Wayne

Lipids@Wayne is a program of Wayne State University researchers from the School of Medicine, Physics and the College of Liberal Arts and Sciences.  Now in our seventh year, our twice-monthly presentations focus on cutting edge research and technological advances in lipid research and lipidomics. These meetings have led to very fruitful collaborations. 

In addition to these presentations, we sponsor an annual symposium that addresses the vital roles of lipids in cellular processes required for normal physiological function. The symposium features excellent plenary lectures from outstanding invited speakers at the cutting edge of lipid research. A poster session is also featured, which fosters discussion and sharing of research findings. Awards are given for the most outstanding posters presented by graduate students, post-doctoral fellows, and residents.

Upcoming Seminar

Wednesday, Feburary 7, 2018

 

Emilio Mottillo, Ph.D.

Post-Doctoral Fellow
CMMG
Wayne State University

 

Illuminating Fatty Acid Metabolism

The balance between fatty acid storage and mobilization is critical to maintaining metabolic health. Thus, improving our understanding of how fatty acid homeostasis is maintained or dysregulated during metabolic disease is of particular importance. The mobilization of fatty acids is tightly regulated by protein-protein interactions that occur on the surface of lipid droplets. In addition, fatty acid metabolism is thought to be compartmentalized; specific metabolites and signals are thought to be generated within particular spatial domains and in a temporal fashion. However, the ability to visualize these metabolic processes with high spatial and temporal resolution have not been possible. To overcome these limitations, we have devised genetically encoded sensors to detect and image the production of fatty acids and their metabolites in brown adipocytes. Use of a bipartite fluorescent fatty acid sensor demonstrates that fatty acids can traffic from the lipid droplet to the nucleus within minutes of stimulating lipolysis to promote a transcriptional program involved in fatty acid oxidation and uncoupling. Furthermore, live imaging of fatty acyl-CoAs in cells utilizing a FRET based sensor demonstrates that long-chain fatty acyl-CoAs locally produced by mitochondria function in a negative feedback loop to inhibit lipolysis. Finally, utilizing fluorescent and luminescent based methods to respectively image and measure protein-protein interactions, we provide evidence that a particular genetic mutation involved in fatty liver disease promotes triglyceride accumulation by impairing fatty acid mobilization. Overall, utilizing various imaging approaches we have illuminated novel pathways that regulate lipid homeostasis and that are dysregulated in metabolic disease.  (Click here to download the flyer)

Seminars are held at 5:00PM in room 1167 in the Biological Sciences building on main campus. Pizza and drinks will be served.

How to Get Involved?

We are always looking for newcomers at both our seminars and annual symposium. Those interested should check the seminar schedule and attend! We welcome all research groups from all departments, even if your primary focus is not lipids.

If you would like to be added to our e-mail list for seminar reminders and other Lipids@Wayne related information, please send an e-mail to lipids@wayne.edu.

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