|Welcome to Lipids @ Wayne|
Lipids@Wayne is a program of Wayne State University researchers from the Schools of Medicine and Engineering and the College of Liberal Arts and Sciences. Now in our sixth year, our twice-monthly presentations focus on cutting edge research and technological advances in lipid research and lipidomics. These meetings have led to very fruitful collaborations.
In addition to these presentations, we sponsor an annual symposium that addresses the vital roles of lipids in cellular processes required for normal physiological function. The symposium features excellent plenary lectures from outstanding invited speakers at the cutting edge of lipid research. A poster session is also featured, which fosters discussion and sharing of research findings. Awards are given for the most outstanding posters presented by graduate students, post-doctoral fellows, and residents.
Wednesday, April 5th
Scott Hansen, Ph.D.
Department of Molecular Medicine & Neuroscience
The Scripps Research Institute
Lipid Raft Disruption and the Molecular Basis of Force Transduction
The sensing of physical force, mechanosensation, underlies two of five human senses-touch and hearing. How transduction of force in a membrane occurs remains unclear. I will discuss a novel kinetic model of force transduce where lipid rafts are dynamic compartments disrupted by force. Rafts inactivate the signalling enzyme phospholipase D2 (PLD2) by sequestering the enzyme from its substrate. Mechanical disruption of the lipid rafts activates PLD2 by mixing the enzyme with its substrate to produce the signalling lipid phosphatidic acid (PA). The process is fast (estimated <650 μs), and establishes a non-tension mechanism for mechanotransduction where disruption of ordered lipids initiates a mechanosensitive signal for cell growth through mechanical mixing of lipids and protein.
Seminars are held in room 1167 at 5:00pm in the Biological Sciences building on Main Campus. For the full seminar schedule, see the seminar schedule page.
We are always looking for newcomers at both our seminars and annual symposium. Those interested should check the seminar schedule and attend! We welcome all research groups from all departments, even if your primary focus is not lipids.
If you would like to be added to our e-mail list for seminar reminders and other Lipids@Wayne related information, please send an e-mail to firstname.lastname@example.org.